We stayed up in La Jolla near the University (of California San Diego), and not far from the Scripps Institute, a famous Oceanographic institute. Also close to our hotel was La Costa, a beautiful golf course that has hosted PGA and LPGA events in the past. The whole area was beautiful! And the weather was really pleasant, even though it rained several days while we were there.
Of course, you can't go to San Diego and not go to the San Diego Zoo. The most famous residents of the zoo are the pandas. There is a mother, daddy and baby panda, but apparently the mom and dad don't get along, so when we were there only the mom and baby were visible.